In the current opioid epidemic, opioid emergencies can arise without warning, among those we didn’t expect to be affected. If you are prepared, you can save lives. This guide shows you how to prepare and what to do. It describes the equipment you need, and the step-by-step procedures you need to know to care for a person in crisis and keep yourself safe. As a rescuer, you may have training in opioid emergency response through your job, or you may no formal training. This guide is for everyone. In an easy-to-scan format, it breaks down information by level of expertise. Use this guide to build on the expertise you have, or to build the expertise you need.