A revealing history of the West that pivots on Native peoples and the mixed families they made with European settlers. There is mixed blood at the heart of America. And at the heart of Native life for centuries there were complex households using marriage to link communities and protect people within circles of kin. These family circles took in European newcomers who followed the fur trade into Indian Country from the Great Lakes to the Columbia River. Vividly combining the panoramic and the particular, Anne F. Hyde's pathbreaking history follows five mixed-descent families whose lives were inscribed by history: corporate battles over control of the fur trade, the extension of American power into the West, the ravages of imported disease, the violence triggered by Indian removal, the incessant battles for land with encroaching American settlement, and the mix of opportunity and disaster in post-Civil War reservations and allotment. Occupying a dangerous intermediate ground in a continent of conflict, mixed-descent families were pivotal in the events that made the West.