The Impossible Clinic explores the conundrum of evidence-based medicine's (EBM) attempt to translate evidence from medical research into recommendations for practice. Ironically, when medical institutions combine disciplinary regulations with EBM to produce clinical practice guidelines, the outcomes are antithetical to the aim. Such guidelines fail to increase individual physicians' capacity to judge - as EBM promises - because they externalize judgment while imposing disciplinary control. The Impossible Clinic is the first book to interrogate the history, practice, and pitfalls of EBM and how it persists due to intersecting relationships between professional medical regulation and liberal governance strategies.