The provision of northern health care entails many unique challenges and circumstances that are rarely represented in mainstream health sciences education. This open access, online resource consists of 38 short chapters from a variety of experts, academics, and practitioners in northern and Indigenous health and health care from around the Circumpolar North on the following themes: health issues in northern and Indigenous communities; health systems and governance; the social determinants of health in northern and Indigenous communities; culture and health; and professional practice in rural/remote/isolated communities. The learning objectives for this open textbook include: understanding the unique healthcare needs and professional responsibilities that result from remoteness and population sparsity; identifying the social, environmental and cultural aspects of a community that inform and impact care needs; appreciating traditional and Indigenous medicines and approaches to healing as part of a holistic care system; and exploring the similarities and differences in northern health care across the circumpolar region.