Everything is falling to pieces for Francesca Thayer. Her relationship with Todd collapses and he moves out. Her leaky house needs total restoration; yet, as the owner of a struggling art gallery, her mortgage still needs paying. So she's forced to advertise for lodgers. First arrives Eileen - a young, schoolteacher from LA. Then comes Chris, a newly divorced father with a difficult ex-wife, and his seven-year-old son who visits every other weekend. Last to arrive is Marya - a famous cookery author wanting to rebuild her life after her husband's death. Francesca finds that her tenants are the most important people in her life - as 44 Charles Street fills with laughter, hope and heartbreak - and discovers that she might be able to open her heart again after all...