Aleksandar and Isobel are siblings and former classical music prodigies, once destined for greatness. As the only Eastern European family growing up on their block on the far southside of Chicago, the pair were inseparable until each was forced to confront the absurdity of tragedy at an early age and abandon their musical ambitions. Now in their twenties, they find themselves encountering ridiculous jobs, unfulfilling romantic relationships, and the outrageousness of ordinary life. Doomed by fate, a family history of failure, an odd mother, an absent father, and a younger brother with a peculiar fondness for catastrophes, the two siblings have all but given up. But when an illness forces Isobel and her three-year-old daughter to move back into the family home, Aleks becomes deeply involved in the endless challenges that surround his relatives. Once Isobel begins playing cello again, Aleks comes to see a world of possibility and wonder in the lives of his extraordinarily complicated family. Told in Aleks's exuberant voice, and full of as much comedy as tragedy, this entertaining novel asks, Is it ever truly possible to separate our fates from those we've come to love?