What causes a nightmare? For federal witness Miles Kendrick it is the crippling memory of killing his best friend. For teenager Amanda Groote it is the terror of being trapped in a car wreck next to her mother's mangled body. They are both patients of psychiatrist Dr. Alison Vance, who is testing an experimental drug that may erase their fears. But when Dr. Vance is murdered, Miles must leave the witness protection program to track down someone who would sacrifice anything to acquire the drug.