Living in relative seclusion, Ev and Ec rely on the kindness of strangers as they struggle with their own internal and external problems. Ev not only suffers from agoraphobia, she believes she is dying from a fatal degenerative disease. Ec, who is obsessed with his eleventh toe (which he has named Toto), is grieving over his estranged fiancée who left him at the altar. Although Ev declares that hell hath no fury like a mother's love, the Nuttalls prove that sometimes family can be your worst enemy.